Phase-3 trial for Panacea Biotech’s Dengue Vaccine
The phase-3 trial of a dengue vaccine developed by Panacea Biotech in collaboration with the Indian Council of Medical Research (ICMR) is likely to begin in August or September 2023.
An overview of the news
Phase-III clinical trial is being done for evaluation of efficacy, along with safety and immunogenicity of tetravalent dengue vaccine.
Serum Institute of India and Panacea Biotech have applied for expression of interest for clinical trials for indigenous manufacturers of dengue vaccine.
What is Dengue?
Commonly known as break bone fever, it is a flu-like illness caused by the dengue virus.
It occurs when an Aedes mosquito carrying the virus bites a healthy person.
The disease is mainly found in tropical and sub-tropical regions of the world.
Causes of Dengue
It is caused due to four viruses, namely - DENV-1, DENV-2, DENV-3, and DENV-4.
The virus enters the mosquito when it bites an already infected person.
The disease is transmitted when it bites a healthy person, and the virus is spread through the person's bloodstream.
Symptoms of Dengue
Headache, Muscle, bone and joint pain, Nausea, Vomiting, swollen glands, Rash.
There is no specific treatment for dengue.
Early detection of severe dengue-associated illness and access to appropriate medical care reduce deaths from severe dengue.
Diagnosis of dengue infection is done with a blood test.
Malaria - This disease is caused by the bite of a female Anopheles mosquito.
Malaria fever is caused by a virus called Plasmodium vivax.
Dengue - Dengue virus is transmitted to humans through the bite of an infected Aedes mosquito.
According to the World Health Organisation (WHO), dengue is the most widely spread disease by mosquitoes worldwide.
Chikungunya - Chikungunya, like dengue, is caused by the bite of the Aedes mosquito.
Yellow Fever - This disease is caused by the bite of a human from the Aedes mosquito, especially Aedes aegypti.
Yellow fever is caused by flavivirus.
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